Most common Molecular Mechanisms of Eye cancer were identified

cancer, eye, Eye cancer, Identified, mechanisms, the eye molecular,

Uveal melanoma is the most common primary ocular tumor in adults, located in either the iris (4%), the ciliary body (6%), or the choroid (90%).

According to and quoted by:

TEUveal melanoma may have no early signs or symptoms. But as a tumor grows, it can cause symptoms such as blurred vision or other vision changes, a dark spot on the iris, a change in the size or sharp of the pupil, and so on.

The most common treatments for molanoma uvea include surgery and radiation therapy. However, when melanoma uvea spreads to other organs, the chances of survivals decrease. The reason why only a certain group of Patient with specific Tumor Characteristics develop uvea metastatic melanoma and the mechanisms that cause metastasis are unknown.

Researchers at the Sloan Catering Memorial Cancer Center in the United States, One of the World’s most prestigious cancer research centers, have now identified the molecular mechanisms that promotes melanoma uvea (UM). This study could lead to the treatment of melanoma uvea for the initial suppression of a fatal tumor.

The Scientists in this study combined several Genetic analyze to find that the progression of melanoma uvea occurs with the loss of the “Polycomb Repressive complex 1” (Proteins that regulate gene expression).

Loss of this group causes abnormal gene expression, and errors in how chromosomes are separated occur during cell division, which ultimately triggers an inflammatory response that makes the tumor more aggression.

“By identifying the key steps involved in tumor progression, we will have an opportunity to begin the process of treating and suppressing the tumor as soon as possible,” said Samuel Bakhoum of the Sloan-Catering Memorial cancer center.


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